Day One
Wednesday, March 27, 2024
8:00 am Registration & Morning Coffee
8:50 am Chair’s Opening Remarks
Delving Into ML & High Throughput to Encourage Desired Alternative Protein Outcomes & Enhanced Efficacy
9:00 am Using High Throughput Synthetic Biology to Encourage Desired Alternative Food Ingredient Outcomes & Enhanced Efficacy
Synopsis
- Discussing how to implement high throughput synthetic biology to ensure you engineer strains with value added on time
- Identifying skills required to create an effective strain engineering pipeline
- Designing an early high-throughput analytical pipeline for food ingredient strain engineering
9:30 am Streamlining Host Selection & Post-Translational Modifications to Produce Desired Function, Taste & Texture
Synopsis
- Adapting your strain in alignment with phosphorylation efforts to enhance desired outcomes
- Exploring advanced high throughput scanning techniques targeted to best select functional proteins producing high titer
- Leveraging predictive ML techniques to direct phosphorylation and disulphide bond modifications for optimal structure, function, and stability
Evolving Your Experimental Design & Strain Engineering to Minimize Trial & Error & Enhance Engineering Speed
10:00 am Advancing from Standard DoE to Active Learning to Select Appropriate Experiments for Strain Optimization
Synopsis
- Leveraging synthetic biology and advanced tools to minimize experimentation and enhance efficiency in the strain optimization process
- Optimizing existing data to inform machine learning models for fit-for-purpose design of experiments
- Understanding how to best adopt comparison of experiments parameters to streamline engineering speed
10:30 am Speed Networking & Morning Coffee Break
11:30 am Curating Robust Strains Equipped to Handle Industrial Relevant Conditions to Minimize Later Stage Failures
Synopsis
- Inducing multi-stress levels in strains to promote tolerance towards temperature changes to minimize production failures
- Assessing how to effectively build a scale down model to predict large scale performance and inform optimal decision making
- Securing compatibility between strains and feedstock to prepare for bioreactor conditions and future-proof protein production
Uncovering Synthetic Biology & Automation Strategies to Carve Out Your Future Strain Engineering With Quick Turnaround & Quality Strains
12:00 pm Fireside Chat: Addressing End-to-End Assessments From Strain Engineering-to- Ingredient Development to Future-Proof Commercialization
Synopsis
- Assessing best platforms using advanced strain engineering tools to promote speed and minimize cost
- Learning how to undertake yield and scalability assessments with partners pre-production to future-proof commercialization
- Addressing and evaluating late-stage ingredient-development to promote commercial use from an ingredient supplier perspective
12:30 pm Continuously Integrating High Throughput Screening & Testing with Cross-Team Feedback for Quicker Strain Optimization
Synopsis
- Implementing high throughput pipelines at all steps of strain development and optimization workflows
- Exploring microfluidic approaches to automate your strain engineering with higher efficiency and consistency
- Addressing how to best automate data management for enhanced detection and decision making
1:00 pm Networking Lunch
2:00 pm Paving the Way for Microfluidics as the Future of Characterization to Set Up for Engineering Success
Synopsis
- Utilizing microfluidics to characterize proteins produced by strains to inform decision making in choice of protein and volume of protein
- Screening orders of magnitude with large biological sets to increase titer and deliver on unit of economics
- Setting up large libraries of characterization for automation to accelerate engineering and minimize time spent in early phases of protein producti
2:30 pm Discussing Strain Optimization Using Computational Models of Gene Expression to Prepare for Future Production
Synopsis
- Monitoring gene expression in your strains via NGS
- Modeling and engineering gene expression to improve growth and production
- Improving genetic stability based on computational models to enhance efficiency
3:00 pm Afternoon Break & Networking
Reaching New Strain Optimization Heights to Prepare for Scalability & Minimize Economic Restraints
3:45 pm Fireside Chat: Exploring Strain Optimization Opportunities to Best Navigate Biological Complexity & Achieve Desired Protein Results
Synopsis
- Exploring how to advance your current strain optimization procedures to accompany protein expectations
- Understanding how to consider yield and scalability considerations during early strain optimization phases
- Discussing ultra-high throughput opportunities to maximize strain modifications fit for production